Sodium Carbonate → HCID 68108684, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave vial was added 5-bromo-2-{[(3,4-difluorophenyl)methyl]oxy}-N-4-pyridazinylbenzamide (may be prepared as described in Example 78; 150 mg, 0.36 mmol), 1,1-dimethylethyl 4-(4,4,5,5-tetramethyl-1,3,2-dioxaborolan-2-yl)-1H-pyrazole-1-carboxylate (116 mg, 0.39 mmol), 1,2-dimethoxyethane (2 ml), 1M sodium carbonate (0.71 ml, 0.71 mmol) and tetrakis(triphenylphosphine)palladium(0) (24.75 mg, 0.02 mmol). The vial was sealed and heated to 120° C. for 25 min under microwave conditions. The mixture was evaporated under reduced pressure. Water (5 ml) was added to the residue and the mixture was extracted with ethyl acetate (3×10 ml). The organics were combined and evaporated under reduced pressure and the residue was purified using the MDAP to yield the title compound. 41 mg.

Provenance & Evidence