Sodium Carbonate → HCID 69936647, compound

Participants

Reaction Conditions

Reaction Steps

To a microwave vial was added 5-bromo-2-([(3,4-difluorophenyl)methyl]oxy)-N-3-pyridinylbenzamide (may be prepared as described in Example 60; 120 mg, 0.29 mmol), 4-pyridinylboronic acid (52.8 mg, 0.43 mmol), tetrakis(triphenylphosphine)palladium(0) (19.85 mg, 0.02 mmol), sodium carbonate (0.57 ml, 0.57 mmol) and 1,2-dimethoxyethane (3 ml). The mixture was sealed and heated to 120° C. for 1 hr under microwave conditions. The 1,2-dimethoxyethane was evaporated under reduced pressure and the residue was purified using MDAP to yield the title compound. 23.5 mg.

Provenance & Evidence