Acetic Acid → HCID 69936850, compound

Participants

Reaction Steps

Morpholine (0.05 ml, 0.54 mmol) and acetic acid (0.03 ml, 0.54 mmol) were added to a solution of 2-{[(3,4-difluorophenyl)methyl]oxy}-5-formyl-N-4-pyridazinylbenzamide (may be prepared by Example 79; 200 mg, 0.54 mmol) in DCE (5 ml), and the mixture was stirred at room temperature for 10 min. Sodium triacetoxyborohydride (172 mg, 0.81 mmol) was then added and the mixture was stirred at 50° C. overnight. Saturated sodium hydrogencarbonate (10 ml) was added and the mixture stirred for 10 min before being diluted with dichloromethane (25 ml). The organic layer was separated and the aqueous phase was extracted with dichloromethane (25 ml). The organics were combined and evaporated under reduced pressure. The residue was purified by MDAP to yield the title compound. 147 mg.

Provenance & Evidence