Acetic Acid → HCID 69936546, compound

Participants

Reaction Steps

Morpholine (0.07 ml, 0.85 mmol) followed by acetic acid (0.03 ml, 0.57 mmol) were added to a suspension of 2-([(4-fluorophenyl)methyl]oxy)-5-formyl-N-4-pyridazinylbenzamide (may be prepared as described in Example 84; 200 mg, 0.57 mmol) in DCE (10 ml). The mixture was stirred at room temperature for 10 min and then sodium triacetoxyborohydride (133 mg, 0.63 mmol) was added. The mixture was warmed to 50° C. for 3 hrs. The reaction mixture was diluted with dichloromethane (25 ml) and saturated sodium hydrogen carbonate was added to this mixture until no effevervesence was observed. The mixture was separated and the organic layer was evaporated under reduced pressure. The residue was purified using MDAP to yield the title compound. 180 mg.

Provenance & Evidence