HCID 24729770, compound → HCID 51030746, compound

HRID 1623970Notes

Reaction equation

HRID 1623970 reaction equation
[N:1]1[CH:6]=[CH:5][N:4]=[CH:3][C:2]=1[N:7]1[C:14]2[C@@H:13]3[CH2:15][C@@H:12]3[CH2:11][C:10]=2[C:9]([C:16]([OH:18])=O)=[N:8]1.[NH2:19][CH:20]([CH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1)[CH2:21][OH:22]>>[OH:22][CH2:21][CH:20]([NH:19][C:16]([C:9]1[C:10]2[CH2:11][C@H:12]3[CH2:15][C@H:13]3[C:14]=2[N:7]([C:2]2[CH:3]=[N:4][CH:5]=[CH:6][N:1]=2)[N:8]=1)=[O:18])[CH:23]1[CH2:28][CH2:27][O:26][CH2:25][CH2:24]1

Participants

3

Reactant 2

HCID 24729770HCID 24729770, compoundHCID 68182505HCID 68182505, compound

Product 1

HCID 51030746HCID 51030746, compound

Procedure

The title compound was prepared in a manner similar to that described in Method G using Intermediate 2 and 2-amino-2-(tetrahydro-2H-pyran-4-yl)ethanol. LCMS m/z=370.2 [M+H]+; 1H NMR (400 MHz, CDCl3) δ ppm 0.46-0.50 (m, 1H), 1.26 (td, J=7.8 and 4.6 Hz, 1H), 1.42-1.54 (m, 2H), 1.72 (d, J=12.6 Hz, 2H), 1.98-2.09 (m, 1H), 2.27-2.34 (m, 1H), 2.51 (bs, 1H), 2.73-2.79 (m, 1H), 2.94 (d, J=16.8 Hz, 1H), 3.01 (dd, J=16.4 and 6.1 Hz, 1H), 3.36-3.45 (m, 2H), 3.82-3.89 (m, 3H), 4.01 (dd, J=11.2 and 4.0 Hz, 2H), 7.11 (d, J=7.6 Hz, 1H), 8.42 (dd, J=2.5 and 1.5 Hz, 1H), 8.51 (d, J=2.4 Hz, 1H), 9.26 (d, J=1.4 Hz, 1H).

Sources & evidence

ORD record
ord-6542ec1d1cc4455e8beb7562cb92acc1
Source dataset
uspto-grants-2014_07
Patent number
US08778950B2

Reaction notes

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