HRID1623980

反应详情

EQUATION

反应方程式

REACTANTS

反应物

HCID53415776

1-(Trifluoromethyl)cyclobutan-1-amine--hydrogen chloride (1/1)

C5H9ClF3N

结构：O=C(O)c1nn(-c2cnccn2)c2c1C[C@@H]1C[C@H]21

HCID68004668

未命名化合物

PRODUCTS

生成物

结构：O=C(NC1(C(F)(F)F)CCC1)c1nn(-c2cnccn2)c2c1C[C@@H]1C[C@H]21

HCID51029727

未命名化合物

PROCEDURE

实验过程

The title compound was prepared in a manner similar to that described in Method UU using Intermediate 4 and 1-(trifluoromethyl)cyclobutanamine hydrochloride. LCMS m/z=364.4 [M+H]+; 1H NMR (400 MHz, CDCl3) δ 0.47 (td, J=4.6, 3.2 Hz, 1H), 1.23-1.29 (m, 1H), 2.04-2.14 (m, 2H), 2.27-2.33 (m, 1H), 2.64-2.70 (m, 4H), 2.74-2.80 (m, 1H), 2.93 (d, J=16.9. Hz, 1H), 3.02 (dd, J=16.6 and 6.2 Hz, 1H), 6.99 (s, 1H), 8.42 (dd, J=2.5 and 1.5 Hz, 1H), 8.52 (d, J=2.5 Hz, 1H), 9.26 (d, J=1.4 Hz, 1H).