HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetaldehyde → 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetaldehyde | HCID 177 | — |
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Sodium cyanoborohydride | HCID 5003444 | — |
| Reactant | 4-amino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide | HCID 19691899 | — |
| Catalyst | Titanium Tetrachloride | HCID 24193 | — |
| Solvent | Methanol | HCID 887 | — |
| Product | 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide | HCID 19691908 | — |
Reaction Steps
A solution of 6 g of 4-amino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide and 0.5 g of titanium tetrachloride in 100 ml of methanol is treated with 1 ml of freshly distilled acetaldehyde. 4 g of sodium cyanoborohydride are then added thereto and the mixture is stirred for 30 hours. Cold half-concentrated hydrochloric acid is added thereto, the mixture is worked up in the customary manner and 4-ethylamino-N-(2,1,3-benzothiadiazol-5-yl)-1-benzenesulfonamide is obtained.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US05726194 |
| Source dataset | uspto-grants-1998_03 |
| ORD ID | ord-a7fa891adf0d455598641c30d6e12a91 |
| Source note | uspto-grants-1998_03 |