Hydrochloric Acid → HCID 178509557, compound

Participants

Reaction Conditions

Reaction Steps

A mixture of 4-[4-hydroxy-1-(p-tolylsulfonyl)-6,7-dihydro-5H-indazol-4-yl]benzonitrile and 4-[4-hydroxy-2-(p-tolylsulfonyl)-6,7-dihydro-5H-indazol-4-yl]benzonitrile (8.56 g, 21.7 mmol) is added to 4.0 M HCl in dioxane (20.0 mL, 80.0 mmol), heated to 80° C. for 2.0 h and concentrated to dryness. The residue is dissolved in dichloromethane/water, separated and the organics are dried over Na2SO4, filtered, and evaporated. The residue is purified by silica gel chromatography 80% ethyl acetate/hexanes to give the title compound (3.21 g, 67%). ES/MS m/z 222 (M+H), 220 (M−H).

Provenance & Evidence