Trifluoroacetic acid → HCID 71114811, compound

Participants

Reaction Steps

4-(4-Chlorophenyl)-2-(p-tolylsulfonyl)-6,7-dihydro-5H-indazol-4-ol (0.76 g, 1.89 mmol) is added to dichloromethane (20.0 mL), triethylsilane (6.04 mL, 37.7 mmol), and TFA (0.16 mL, 2.07 mmol) and stirred at room temperature for 2.0 h. The reaction is quenched with saturated NaHCO3, separated, the organics washed with brine dried over Na2SO4, filtered, and evaporated to dryness to give the title compound (0.622 g, 86%). 1H NMR (CDCl3) δ 2.42 (s, 3H), 2.55 (m, 2H), 2.82 (t, 2H), 5.98 (t, 1H), 7.37-7.31 (m, 6H), 7.81 (s, 1H), 7.87 (d, 2H).

Provenance & Evidence