Water → HCID 89286942, compound

HRID 1624042Notes

Reaction equation

HRID 1624042 reaction equation
[CH3:1][C:2]1([CH3:18])[C:6]2[NH:7][N:8]=[CH:9][C:5]=2[C@@H:4]([C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][CH:11]=2)[CH2:3]1.[OH2:19]>>[OH2:19].[CH3:1][C:2]1([CH3:18])[C:6]2[NH:7][N:8]=[CH:9][C:5]=2[C@@H:4]([C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][CH:11]=2)[CH2:3]1.[CH3:1][C:2]1([CH3:18])[C:6]2[NH:7][N:8]=[CH:9][C:5]=2[C@@H:4]([C:10]2[CH:17]=[CH:16][C:13]([C:14]#[N:15])=[CH:12][CH:11]=2)[CH2:3]1

Participants

3

Reactant 2

HCID 962WaterHCID 71114804HCID 71114804, compound

Product 1

HCID 89286942HCID 89286942, compoundYield 76%

Procedure

Suspend 4-[(4R)-(6,6-dimethyl-4,5-dihydro-1H-cyclopenta[c]pyrazol-4-yl)]benzonitrile (45 mg, 0.190 mmol) in water (1 mL) and slurry at ambient temperature for 1 hour. The solids are vacuum filtered and air dried to give the title compound (35 mg, 76%).

Workup

  1. filtrationfiltered
  2. customair dried

Sources & evidence

ORD record
ord-abc39072492e4740ab5dd4e25078de6a
Source dataset
uspto-grants-2014_07
Patent number
US08778984B2

Reaction notes

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