反应详情

(+/−)-(cis/trans)-4-[7-Methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl]benzonitrile (0.36 g, 1.52 mmol) and (+/−)-(trans)-4-[7-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl]benzonitrile (0.18 g, 0.76 mmol) are combined and the single enantiomers are obtained by chiral chromatography (Chiralpak AD-H, 4.6×150 mm, 100% EtOH 0.2% DMEA, 225 mm) to give (cis)-4-[7-methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl]benzonitrile-isomer 2, (0.05 g, 27%) as the second eluting isomer. ES/MS m/z 238 (M+H), Tr=2.988 min. (trans)-4-[7-Methyl-4,5,6,7-tetrahydro-2H-indazol-4-yl]benzonitrile-isomer 4, Example 61 (0.07 g, 19%). ES/MS m/z 238 (M+H).