反应详情

With ice cooling, 30 g of 5-chloropyridin-3-ol (232 mmol, 1 equivalent) were dissolved in 228 ml of concentrated sulphuric acid, and, at 0° C., 24 ml of concentrated nitric acid were added slowly. The reaction was warmed to RT and stirred overnight. The mixture was stirred into an ice/water mixture and stirred for another 30 min. The solid was filtered off, washed with cold water and air-dried. This gave 33 g (82% of theory) of the title compound, which were used without further purification for the next reaction.

1. stirringstirred for another 30 min
2. filtrationThe solid was filtered off
3. washwashed with cold water
4. customair-dried
5. customThis gave 33 g (82% of theory) of the title compound, which were used without further purification for the next reaction