Sulfuryl chloride → 1033707-26-4

HRID 1624080Notes

Reaction equation

HRID 1624080 reaction equation
S(Cl)([Cl:4])(=O)=O.[CH:6]1([C:9](=[O:16])[CH2:10][C:11]([O:13][CH2:14][CH3:15])=[O:12])[CH2:8][CH2:7]1>ClCCl>[Cl:4][CH:10]([C:9]([CH:6]1[CH2:8][CH2:7]1)=[O:16])[C:11]([O:13][CH2:14][CH3:15])=[O:12]

Participants

4

Reactant 2

HCID 24648Sulfuryl chlorideHCID 262979Ethyl 3-cyclopropyl-3-oxopropanoate

Product 1

HCID 542445011033707-26-4

Reagents, catalysts & solvents 1

HCID 6344DichloromethaneSolvent

Procedure

3.1 ml of sulphuryl chloride (38.2 mmol, 1.05 equivalents) were initially charged in 21 ml of dichloromethane, and 5.68 g of ethyl 3-cyclopropyl-3-oxopropanoate (36.4 mmol) were added dropwise on a water bath. The reaction mixture was stirred at RT for 2 h and then washed with water, 5% strength aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution, dried over magnesium sulphate and concentrated. The crude product (6.8 g) was used without further purification for the next reaction.

Workup

  1. washwashed with water, 5% strength aqueous sodium bicarbonate solution and saturated aqueous sodium chloride solution
  2. dry with materialdried over magnesium sulphate
  3. concentrationconcentrated
  4. customThe crude product (6.8 g) was used without further purification for the next reaction

Sources & evidence

ORD record
ord-42abd7139bc447f6b989d8d0993b7bcd
Source dataset
uspto-grants-2014_07
Patent number
US08778964B2

Reaction notes

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