HCID 86717937, compound → 2-Amino-4-fluoropyridin-3-ol

HRID 1624119Notes

Reaction equation

HRID 1624119 reaction equation
[F:1][C:2]1[CH:7]=[CH:6][N:5]=[C:4]([N+:8]([O-])=O)[C:3]=1[OH:11]>C(O)C.[Pd]>[NH2:8][C:4]1[C:3]([OH:11])=[C:2]([F:1])[CH:7]=[CH:6][N:5]=1

Participants

4

Reactant 1

HCID 86717937HCID 86717937, compound

Product 1

HCID 214366942-Amino-4-fluoropyridin-3-ol

Reagents, catalysts & solvents 2

HCID 23938PalladiumCatalystHCID 702EthanolSolvent

Procedure

Under argon, 90 mg (0.57 mmol) of 4-fluoro-2-nitropyridin-3-ol Example 108A were dissolved in 30 ml of ethanol, and a spatula tip of palladium on activated carbon (10%) was added. The mixture was hydrogenated at RT under reduced pressure for 1.5 h. The reaction mixture was filtered off through silica gel and the filter cake was washed with plenty of ethanol. The solution was concentrated and dried. This gave 56 mg (77% of theory) of the title compound.

Workup

  1. filtrationThe reaction mixture was filtered off through silica gel
  2. washthe filter cake was washed with plenty of ethanol
  3. concentrationThe solution was concentrated
  4. customdried

Sources & evidence

ORD record
ord-ab89a6b7b2954783916f3e6ee4525f5f
Source dataset
uspto-grants-2014_07
Patent number
US08778964B2

Reaction notes

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