Hydrazine → HCID 59262506, compound

HRID 1624162Notes

Reaction equation

HRID 1624162 reaction equation
C([O:3][C:4](=O)[C:5]([S:8](=[O:17])(=[O:16])[NH:9][CH:10]1[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1)([CH3:7])[CH3:6])C.[NH2:19][NH2:20]>C(O)C>[CH:10]1([NH:9][S:8]([C:5]([C:4]([NH:19][NH2:20])=[O:3])([CH3:7])[CH3:6])(=[O:17])=[O:16])[CH2:15][CH2:14][CH2:13][CH2:12][CH2:11]1

Participants

4

Reactant 2

HCID 9321HydrazineHCID 129373992-Cyclohexylsulfamoyl-2-methylpropionic acid ethyl ester

Product 1

HCID 59262506HCID 59262506, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Using a method similar to that described by S. Paik and E. H. White (Tetrahedron, 1996, 52, 5303), 2-cyclohexylsulfamoyl-2-methylpropionic acid ethyl ester DF1 (which is prepared by the method of A. De Blic et al. (Synthesis, 1982, 281)) in ethanol is treated with 1.2 equivalent of 95% hydrazine under N2 and the mixture is allowed to stand at RT for 12 h. The reaction mixture is concentrated to give the title compound DF2 which is used directly in Step 2.

Workup

  1. concentrationThe reaction mixture is concentrated

Sources & evidence

ORD record
ord-3ca651286e6a47b4aa28294d8ffd5dd0
Source dataset
uspto-grants-2014_07
Patent number
US08778980B2

Reaction notes

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