HuagongsheHuagongshe Chemistry Print Report · For research reference only
Dimethylformamide dimethyl acetal → ethyl (Z)-3-(dimethylamino)-2-[4-[(E)-dimethylaminomethylideneamino]-2-methylsulfanyl-1,3-thiazole-5-carbonyl]prop-2-enoate
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Dimethylformamide dimethyl acetal | HCID 78373 | — |
| Reactant | Ethyl 3-(4-amino-2-methylthiothiazol-5-yl)-3-oxopropanoate | HCID 2807782 | — |
| Solvent | Toluene | HCID 1140 | — |
| Product | ethyl (Z)-3-(dimethylamino)-2-[4-[(E)-dimethylaminomethylideneamino]-2-methylsulfanyl-1,3-thiazole-5-carbonyl]prop-2-enoate | HCID 13297627 | — |
Reaction Steps
A mixture of EXAMPLE 1A (8.8 g) and N,N-dimethyl-formamide dimethyl acetal (15.1 g) in toluene (170 mL) at 110° C. was stirred for 3 hours, concentrated to half volume, cooled, and filtered. 1H NMR (300 MHz, CDCl3) δ 8.40 (s, 1H), 7.42 (s, 1H), 3.99 (q, 2H), 3.05 (d, 6H), 2.92 (b, 6H), 2.65 (s, 3H), 1.04 (t, 3H).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US07737159B2 |
| Source dataset | uspto-grants-2010_06 |
| ORD ID | ord-eddc73aee2034edd9b0b0809e72fd0fc |
| Source note | uspto-grants-2010_06 |