Carbon Dioxide → HCID 68242896, compound

Participants

Reaction Steps

1 mmol of 2-methylthieno[3,4-d][1,3]thiazole represented by formula (12) was dissolved in 10 ml of tetrahydrofuran and kept at −78° C. in a methanol-bath cooled by dry ice. Into this solution, a solution comprised of 1.05 mmol of N-bromosuccinimide and 5 ml of tetrahydrofran was gradually added dropwise. After two hours reaction, an excess amount of a saturated sodium chloride aqueous solution was added to stop the reaction. The reacted liquid was washed with water, and the organic layer was recovered and dried under sodium sulfate. The solvent was evaporated out and then purification was carried out using column separation method with solvents of ethylacetate and hexane, obtaining 6-bromo-2-methylthieno[3,4-d][1,3]thiazole represented by formula (13).

Provenance & Evidence