反应详情

温度

80 °C

5 mmol of 4-(mercaptomethyl)-2-methyl-1,3-oxazole-5-carbaldehyde was described in 50 ml of ethanol, then 50 mmol of acetic acid was added. Stirring was continued for 1 hour at a room temperature and the temperature was heated up to 80° C. to carry out the reaction for 4 hours. The reacted liquid was cooled down to a room temperature and the solvent was evaporated out. The product was purified using column separation with the solvents of ethylacetate and hexane, obtaining 2-methylthieno[3,4-d][1,3]oxazole.

1. customthe reaction for 4 hours
2. temperatureThe reacted liquid was cooled down to a room temperature
3. customthe solvent was evaporated out
4. customThe product was purified
5. customcolumn separation with the solvents of ethylacetate and hexane