HuagongsheHuagongshe Chemistry Print Report · For research reference only
Acetic Acid → HCID 67272553, compound
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Acetic Acid | HCID 176 | — |
| Reactant | tert-Butyl 4-oxopiperidine-1-carboxylate | HCID 735900 | — |
| Reactant | Sodium triacetoxyborohydride | HCID 5049666 | — |
| Reactant | 8-Amino-5,6,7,8-tetrahydroquinoline | HCID 11355564 | — |
| Solvent | Tetrahydrofuran | HCID 8028 | — |
| Product | HCID 67272553 | HCID 67272553 | 98% |
Reaction Steps
Using general procedure B: Reaction of Boc-4-piperidone (641 mg, 3.22 mmol 5,6,7,8-Tetrahydro-quinolin-8-ylamine (476 mg, 3.22 mmol), sodium triacetoxyborohydride (1.36 g, 6.44 mmol) and acetic acid (0.25 mL) in THF (25 mL) at room temperature under N2 for 20 min afforded the title compound (1.05 g, 98%) as a yellow oil.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08778967B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-b11e58c954164c23967514cdebf6cc48 |
| Source note | uspto-grants-2014_07 |