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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 162432Generated: October 26, 2026

Hydrochloric Acid → N-[(1RS,2SR)-1-[3-(1,1-difluoroethyl)benzyl]-2-(4-fluorophenyl)-2-hydroxyethyl]-4-fluoro-1-naphthamide

https://huagongshe.com/reaction/162432

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
ReactantWaterHCID 962—
ReactantAcetonitrileHCID 6342—
ReactantEthyl AcetateHCID 8857—
Reactant1-Ethyl-3-(3'-dimethylaminopropyl)carbodiimideHCID 15908—
Reactant4-Fluoro-1-naphthoic acidHCID 68448—
Reactant1-HydroxybenzotriazoleHCID 75771—
Reactant(1RS,2SR)-2-amino-3-[3-(1,1-difluoroethyl)phenyl]-1-(4-fluorophenyl)-1-propanolHCID 22261599—
ProductN-[(1RS,2SR)-1-[3-(1,1-difluoroethyl)benzyl]-2-(4-fluorophenyl)-2-hydroxyethyl]-4-fluoro-1-naphthamideHCID 22262091—

Provenance & Evidence

DOI10.1039/C8SC04228D
Source datasetTraining data from https://doi.org/10.1039/C8SC04228D (9/10)
ORD IDord-d5bd61a1834d4efba65ee3a15cd98779
Source noteTraining data from https://doi.org/10.1039/C8SC04228D (9/10)