HuagongsheHuagongshe Chemistry Print Report · For research reference only
Phosphorus tribromide → 4-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Phosphorus tribromide | HCID 24614 | — |
| Reactant | [5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol | HCID 58218538 | — |
| Solvent | 1,2-Dimethoxyethane | HCID 8071 | — |
| Product | 4-Bromomethyl-5-(4-bromo-phenyl)-3-methyl-isoxazole | HCID 66577223 | — |
Reaction Steps
[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-methanol (2.88 g, 10.74 mmol) in DME (23 mL) was treated with phosphorus tribromide (1.5 mL, 16.11 mmol), and the reaction was stirred at room temperature for 1 hour. Aqueous workup provided the title compound.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08778983B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-8228ee2724714d35baa3154f814baca5 |
| Source note | uspto-grants-2014_07 |