Phenylacetyl chloride → 2-Benzyl-5-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylmethyl]-[1,3,4]oxadiazole

HRID 1624401Notes

Reaction equation

[Br:1][C:2]1[CH:7]=[CH:6][C:5]([C:8]2[O:12][N:11]=[C:10]([CH3:13])[C:9]=2[CH2:14][C:15]([NH:17][NH2:18])=[O:16])=[CH:4][CH:3]=1.[C:19]1([CH2:25][C:26](Cl)=O)[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1>>[CH2:25]([C:26]1[O:16][C:15]([CH2:14][C:9]2[C:10]([CH3:13])=[N:11][O:12][C:8]=2[C:5]2[CH:6]=[CH:7][C:2]([Br:1])=[CH:3][CH:4]=2)=[N:17][N:18]=1)[C:19]1[CH:24]=[CH:23][CH:22]=[CH:21][CH:20]=1

Participants

Reactant 2

HCID 7679Phenylacetyl chloride

HCID 66577599[5-(4-Bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid hydrazide

Product 1

HCID 665793322-Benzyl-5-[5-(4-bromo-phenyl)-3-methyl-isoxazol-4-ylmethyl]-[1,3,4]oxadiazole

Procedure

Prepared according to the procedure described in Example 8, Step 6, using [5-(4-bromo-phenyl)-3-methyl-isoxazol-4-yl]-acetic acid hydrazide and phenylacetyl chloride.

Workup

customPrepared

Sources & evidence

ORD record: ord-089144fd597848e8bd30e759c84a81fa
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08778983B2

Reaction notes

Loading…