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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1624442Generated: November 1, 2026

Cesium carbonate → HCID 66577649, compound

https://huagongshe.com/reaction/1624442

Reaction equation

Participants

RoleNameHCIDCharge
ReactantCesium carbonateHCID 10796—
Reactant2-Bromo-6-phenylpyridineHCID 568679—
ReactantBinap, (A+-)-HCID 634876—
Reactant1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl esterHCID 66577195—
SolventTolueneHCID 1140—
ProductHCID 66577649HCID 66577649—

Reaction Steps

1-[4′-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester (0.250 g, 0.689 mmol), 2-bromo-6-phenyl-pyridine (0.1457 g, 0.62 mmol), cesium carbonate (0.2694 g, 0.826 mmol) and (±)-2,2′-bis(diphenylphosphino)-1,1′-binaphthyl (0.032 g, 0.052 mmol) were dissolved in toluene (3 mL) and the solution was degassed with bubbling N2 (g).

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08778983B2
Source datasetuspto-grants-2014_07
ORD IDord-7ade0253313f4120b006496ec8808659
Source noteuspto-grants-2014_07