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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1624455Generated: November 1, 2026

2-Bromo-6-phenylpyrazine → 1-{4'-[3-Methyl-4-(6-phenyl-pyrazin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl ester

https://huagongshe.com/reaction/1624455

Reaction equation

Participants

RoleNameHCIDCharge
Reactant2-Bromo-6-phenylpyrazineHCID 45788327—
Reactant1-[4'-(4-Amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl esterHCID 66577195—
Product1-{4'-[3-Methyl-4-(6-phenyl-pyrazin-2-ylamino)-isoxazol-5-yl]-biphenyl-4-yl}-cyclopropanecarboxylic acid ethyl esterHCID 66577706—

Reaction Steps

Prepared according to the procedure described in Example 41, Step 2, using 1-[4′-(4-amino-3-methyl-isoxazol-5-yl)-biphenyl-4-yl]-cyclopropanecarboxylic acid ethyl ester and 2-bromo-6-phenyl-pyrazine.

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08778983B2
Source datasetuspto-grants-2014_07
ORD IDord-c660c548a2234e77a12addf162014b84
Source noteuspto-grants-2014_07