Methanol → HCID 59515749, compound

HRID 1624992Notes

Reaction equation

HRID 1624992 reaction equation
[OH:1][CH2:2][CH2:3][N:4]1[CH:13]=[CH:12][C:11]2[C:6](=[CH:7][CH:8]=[CH:9][C:10]=2[N+:14]([O-])=O)[C:5]1=[O:17].CO.[H][H]>>[NH2:14][C:10]1[CH:9]=[CH:8][CH:7]=[C:6]2[C:11]=1[CH:12]=[CH:13][N:4]([CH2:3][CH2:2][OH:1])[C:5]2=[O:17]

Participants

4

Reactant 3

HCID 887MethanolHCID 59515678HCID 59515678, compoundHCID 178418361HCID 178418361, compound

Product 1

HCID 59515749HCID 59515749, compound

Procedure

Into a 500 ml round bottom flask was combined 2-(2-hydroxyethyl)-5-nitroisoquinolin-1(2H)-one (2.0 g, 0.0085 mol) palladium on C (0.09 g, 0.0008 mol), and methanol (100 mL, 2 mol). The vessel was charged with hydrogen and evacuated three times and stirred under hydrogen at 1 atm. overnight. The mixture was filtered over Celite and the filtrate was removed under reduced pressure to yield the title compound as a light brown solid. It was taken onto the next step without further purification.

Workup

  1. customInto a 500 ml round bottom flask was combined
  2. customevacuated three times
  3. filtrationThe mixture was filtered over Celite
  4. customthe filtrate was removed under reduced pressure

Sources & evidence

ORD record
ord-0529879ed90f4890a8a79e1ea2e4f87b
Source dataset
uspto-grants-2014_07
Patent number
US08779144B2

Reaction notes

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