Methanol → HCID 24804392, compound

Participants

Reaction Steps

2-(5-(4-Chloro-3-(trifluoromethyl)benzylcarbamoyl)-1-oxoisoquinolin-2(1H)-yl)propane-1,3-diyl diacetate (100 mg, 0.0002 mol), potassium carbonate (80 mg, 0.0006 mol) and methanol (2 mL, 0.05 mol) were stirred at room temperature for 2 hours. The mixture was filtered and purified via flash chromatography (12 g fo silica gel, 0-10% MeOH/CH2Cl2) to give a white solid. 1H NMR (DMSO-d6) δ: 9.18 (br, 1H), 8.35 (d, J=7.6 Hz, 1H), 7.86-7.82 (m, 2H), 7.75-7.70 (m, 2H), 7.55-7.27 (m, 2H), 6.79 (d, J=7.9 Hz, 1H), 4.95-4.89 (m, 3H), 4.56 (d, J=5.9 Hz, 2H), 3.75-3.71 (m, 4H),

Provenance & Evidence