1,4-Dioxane → HCID 24804719, compound

Participants

Reaction Conditions

Reaction Steps

A 5-mL process vial was charged with (R)-2-(5-iodo-1-oxoisoquinolin-2(1H)-yl)propanamide (250 mg, 0.00073 mol), 1-adamantanemethylamine (400 mg, 0.002 mol), molybdenum hexacarbonyl (200 mg, 0.0007 mol), palladium acetate (20 mg, 0.00007 mol), 1,8-diazabicyclo[5.4.0]undec-7-ene (300 mg, 0.002 mol); and 1,4-dioxane (3 mL, 0.04 mol). The vessel was sealed under air and exposed to microwave heating for 15 min at 110° C. The reaction tube was thereafter cooled to room temperature, and the mixture was concentrated and dissolved in a small volume of dichloromethane. The crude product was purified via flash column chromatography (12 g of silica gel, 50-100% etOAC/Hexane) to give the desired product as a white solid.

Provenance & Evidence