Hydrochloric Acid → HCID 86670660, compound

Participants

Reaction Steps

Aqueous HCl (1.42 mL, 1.42 mmol) was added to a solution of (2R)-4-[4-(2,2-Difluoro-1,3-benzodioxol-5-yl)-5-fluoro-2-oxopyridin-1(2H)-yl]-2-methyl-2-(methylsulfonyl)-N-(tetrahydro-2H-pyran-2-yloxy)butanamide (259 mg, 0.474 mmol) in ethanol (5 mL) and water (2 mL) and the reaction was stirred overnight at rt. The solid was collected via filtration, washed with water (5×3 mL) and dried under reduced pressure to afford the title compound (143 mg, 65.3%). 1H NMR (400 MHz, DMSO-d6) d ppm 1.58 (s, 3 H) 2.07-2.24 (m, 1 H) 2.36-2.49 (m, 1 H) 3.11 (s, 3 H) 3.68-3.86 (m, 1 H) 3.98-4.13 (m, 1 H) 6.58 (d, J=7.61 Hz, 1 H) 7.36-7.49 (m, 1 H) 7.55 (d, J=8.39 Hz, 1 H) 7.68 (s, 1 H) 8.06 (d, J=6.63 Hz, 1 H) 9.24 (br. s., 1 H) 11.08 (s, 1 H).

Provenance & Evidence