1H-Pyrazol-3-amine, 5-methyl- → N-(5-methyl-1H-pyrazol-3-yl)acetamide

HRID 1625060Notes

Reaction equation

HRID 1625060 reaction equation
[NH:1]1[CH:5]=[CH:4][C:3]([NH:6][C:7](=[O:9])[CH3:8])=[N:2]1.[CH3:10]C1NN=C(N)C=1>>[CH3:10][C:5]1[NH:1][N:2]=[C:3]([NH:6][C:7](=[O:9])[CH3:8])[CH:4]=1

Participants

3

Reactant 2

HCID 931461H-Pyrazol-3-amine, 5-methyl-HCID 178474341HCID 178474341, compound

Product 1

HCID 5246311N-(5-methyl-1H-pyrazol-3-yl)acetamideYield 70.4%

Procedure

Title compound was prepared by a method analogous to that described for Intermediate 1, replacing 1H-pyrazol-3-amine with 5-methyl-1H-pyrazol-3-amine, (ALDRICH, 1.01 g, 7.25 mmol, 70.4% yield). 1H NMR (300 MHz, DMSO-d6) δ ppm: 11.89 (s, 1H), 10.16 (s, 1H), 6.22 (s, 1H), 2.16 (s, 3H), 1.94 (s, 3H). [ES+MS] m/z 140 (MH+).

Sources & evidence

ORD record
ord-02ea37c47ad54703ac36850fe2490f62
Source dataset
uspto-grants-2014_07
Patent number
US08779153B2

Reaction notes

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