Phosphoric Acid → HCID 178434041, compound

HRID 1625091Notes

Reaction equation

HRID 1625091 reaction equation
[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:32][CH2:31][C:30]([F:34])([F:33])[CH2:29][CH2:28]4)=[O:26])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>CC(C)=O>[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:28][CH2:29][C:30]([F:34])([F:33])[CH2:31][CH2:32]4)=[O:26])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38]([O-:42])([O-:41])([O-:40])=[O:39]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 178434039HCID 178434039, compound

Product 1

HCID 178434041HCID 178434041, compound

Reagents, catalysts & solvents 1

HCID 180AcetoneSolvent

Procedure

Maraviroc (50 gm) was dissolved in acetone (400 ml) and stirred for 30 minutes at room temperature to obtain a solution. To the solution was added phosphoric acid (11 gm) and stirred for 11 hours at room temperature. The solid obtained was collected by filtration and dried to obtain 55 gm of crystalline form 1 of maraviroc phosphate.

Workup

  1. customto obtain a solution
  2. stirringstirred for 11 hours at room temperature
  3. customThe solid obtained
  4. filtrationwas collected by filtration
  5. customdried

Sources & evidence

ORD record
ord-8ee9d1e9713f4092a96ed5775b77d8f4
Source dataset
uspto-grants-2014_07
Patent number
US08779143B2

Reaction notes

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