Phosphoric Acid → HCID 178434041, compound

HRID 1625094Notes

Reaction equation

HRID 1625094 reaction equation
[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:32][CH2:31][C:30]([F:34])([F:33])[CH2:29][CH2:28]4)=[O:26])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>C(C(C)=O)C>[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:28][CH2:29][C:30]([F:34])([F:33])[CH2:31][CH2:32]4)=[O:26])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38]([O-:42])([O-:41])([O-:40])=[O:39]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 178434039HCID 178434039, compound

Product 1

HCID 178434041HCID 178434041, compound

Reagents, catalysts & solvents 1

HCID 6569Methyl Ethyl KetoneSolvent

Procedure

Maraviroc (10 gm) was dissolved in methyl ethyl ketone (100 ml) and stirred for 30 minutes at room temperature. To the solution was added phosphoric acid (2 gm) and stirred for 11 hours at room temperature. The solid obtained was collected by filtration and dried to obtain 10 gm of crystalline form 1 of maraviroc phosphate.

Workup

  1. stirringstirred for 11 hours at room temperature
  2. customThe solid obtained
  3. filtrationwas collected by filtration
  4. customdried

Sources & evidence

ORD record
ord-726a39c5496742279f6d5dad828759f9
Source dataset
uspto-grants-2014_07
Patent number
US08779143B2

Reaction notes

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