Phosphoric Acid → HCID 178434041, compound

HRID 1625097Notes

Reaction equation

HRID 1625097 reaction equation
[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:32][CH2:31][C:30]([F:34])([F:33])[CH2:29][CH2:28]4)=[O:26])[C:18]4[CH:19]=[CH:20][CH:21]=[CH:22][CH:23]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38](=[O:42])([OH:41])([OH:40])[OH:39]>C(O)C>[CH3:1][C:2]1[N:6]([C@H:7]2[CH2:13][C@H:12]3[N:14]([CH2:15][CH2:16][C@H:17]([NH:24][C:25]([CH:27]4[CH2:28][CH2:29][C:30]([F:34])([F:33])[CH2:31][CH2:32]4)=[O:26])[C:18]4[CH:23]=[CH:22][CH:21]=[CH:20][CH:19]=4)[C@H:9]([CH2:10][CH2:11]3)[CH2:8]2)[C:5]([CH:35]([CH3:37])[CH3:36])=[N:4][N:3]=1.[P:38]([O-:42])([O-:41])([O-:40])=[O:39]

Participants

4

Reactant 2

HCID 1004Phosphoric AcidHCID 178434039HCID 178434039, compound

Product 1

HCID 178434041HCID 178434041, compound

Reagents, catalysts & solvents 1

HCID 702EthanolSolvent

Procedure

Maraviroc (10 gm) was dissolved in ethanol (900 ml), and stirred for 30 minutes at room temperature. To the solution was added phosphoric acid (20 gm) and then cooled to 0 to 5° C. The reaction mass was stirred for 11 hours at 0 to 5° C. and filtered. The solid obtained was dried to obtain 10 gm of crystalline form 4 of maraviroc phosphate.

Workup

  1. temperaturecooled to 0 to 5° C
  2. stirringThe reaction mass was stirred for 11 hours at 0 to 5° C.
  3. filtrationfiltered
  4. customThe solid obtained
  5. customwas dried

Sources & evidence

ORD record
ord-bf505f153b8a441c8dda45dd2ef31e92
Source dataset
uspto-grants-2014_07
Patent number
US08779143B2

Reaction notes

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