Pipecolic Acid → HCID 67060270, compound

Participants

Reaction Steps

A mixture of pipecolinic acid (500 mg; 3.87 mmol), 2-methoxy-4-nitrophenylisocyanate (902 mg; 4.65 mmol) and 9:1 THF:2 M NaOH were reacted in a microwave vessel at 160° C. for 10 min. The reaction mixture was then cooled to rt and purified by column chromatography (1:1, EtOAc:hexanes) to afford 736 mg of 2-(2-methoxy-4-nitrophenyl)tetrahydroimidazo[1,5-a]pyridine-1,3(2H,5H)-dione, 1.1.1, (62%).

Provenance & Evidence