HCID 13922753, compound → HCID 58188811, compound

Participants

Reaction Conditions

Reaction Steps

D6 (prepared according to Description 6) (1.0 g; 2.48 mmol) was added to a mixture of 3-hydrazinyl-N,N-dimethylpropanamide (0.65 g; 4.95 mmol) in t-BuOH (20 ml) and the reaction mixture stirred at 150° C. for 16 h. The solvent was then evaporated in vacuo and the residue purified by flash chromatography over silica gel (Biotage flash purification system: gradient acetone/heptane from 20/80 to 50/50). The solvent was then evaporated in vacuo and two fractions were collected. The desired fraction yielded 0.40 g of E1 (34.3%).

Provenance & Evidence