HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 3-[(3,4-difluorophenyl)amino]-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-1-acetic acid ethyl ester
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | Potassium Carbonate | HCID 11430 | — |
| Reactant | Acetic acid, 2-hydrazinyl-, ethyl ester | HCID 12509 | — |
| Reactant | (2Z)-3-[(3,4-difluorophenyl)amino]-1-(2,3-dihydro-1,4-benzodioxin-6-yl)-3-(methylthio)-2-propen-1-one | HCID 66911477 | — |
| Solvent | tert-Butanol | HCID 6386 | — |
| Product | 3-[(3,4-difluorophenyl)amino]-5-(2,3-dihydro-1,4-benzodioxin-6-yl)-1H-pyrazole-1-acetic acid ethyl ester | HCID 58188810 | — |
Reaction Steps
A mixture of D16 (0.00138 mol), 2-hydrazinyl-acetic acid ethyl ester.monohydrochloride (1:1) (0.00276 mol) and K2CO3 (0.00206 mol) in t-BuOH (100 ml) was stirred at 85° C. overnight in a sealed reaction vessel. The reaction mixture was cooled, filtered and the filtrate's solvent evaporated in vacuo. Yield: 0.55 g of E10 (96.5%).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08779158B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-cbdfffc132fb4b6a9fd6b93ec5dd1fb3 |
| Source note | uspto-grants-2014_07 |