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Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester → HCID 178423965、化合物
関与物質
| 役割 | 名称 | HCID | 仕込み量 |
|---|---|---|---|
| 反応物 | Z-O-tert-butyl-L-serine N-hydroxysuccinimide ester | HCID 2729196 | — |
| 反応物 | Purine, 6-bromo- | HCID 5287830 | — |
| 反応物 | 2-Amino-6-bromopurine | HCID 6101139 | — |
| 反応物 | (2,5-Dioxopyrrolidin-1-yl) 2-(phenylmethoxycarbonylamino)butanoate | HCID 12961228 | — |
| 反応物 | HCID 178423963 | HCID 178423963 | — |
| 反応物 | HCID 178456854 | HCID 178456854 | — |
| 溶媒 | Trifluoroacetic acid | HCID 6422 | — |
| 生成物 | HCID 178423965 | HCID 178423965 | — |
反応手順
Compound 68 was prepared using the general procedure described above with respect to compound 14, but 2-benzyloxycarbonylamino-3-tert-butoxy-propionic acid 2,5-dioxo-pyrrolidin-1-yl ester was substituted for 2-benzyloxycarbonylaminobutyric acid 2,5-dioxo-pyrrolidin-1-yl ester in step B, and 2-amino-6-bromopurine was substituted for 6-bromopurine in step D. The obtained 2-[1-(2-amino-9H-purin-6-ylamino)-2-tert-butoxy-ethyl]-5-methyl-3-phenyl-3H-quinazolin-4-one was then dissolved in trifluoroacetic acid and allowed to stir at ambient temperature for 5 hours. Purification by LC provided the product 68 as a white solid. MS (ES): m/z 429 (M+H), 215, 206, 151. Compound 68 is shown below.
情報源と証拠
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| 特許番号 | US08779131B2 |
| 出典データセット | uspto-grants-2014_07 |
| ORD ID | ord-b23088d2af30439b9c183abe874574d0 |
| 出典メモ | uspto-grants-2014_07 |