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HuagongsheHuagongshe Chemistry Print Report · For research reference only
HRID 1625150Generated: November 1, 2026

Hydrochloric Acid → HCID 178466584, compound

https://huagongshe.com/reaction/1625150

Reaction equation

Participants

RoleNameHCIDCharge
ReactantHydrochloric AcidHCID 313—
Reactant5-Methyl-2-(1-[9-(2-trimethylsilylethoxymethyl)-9H-purin-6-ylamino]ethyl)-3-(3-trimethylsilylethynyiphenyl)-3H-quinazolin-4-oneHCID 67103558—
Reactant3-(3-hydroxy-phenyl)-5-methyl-2-[1-(9H-purin-6-ylamino)-ethyl]-3H-quinazolin-4-oneHCID 178423955—
SolventMethanolHCID 887—
ProductHCID 178466584HCID 178466584—

Reaction Steps

Compound 139 was treated with 4N HCl in MeOH at 70° C. for 16 hours in accordance with the procedure described for compound 121 (step D). This reaction afforded compound 144, the structure of which is shown below. m/z=440 (M+H)

Provenance & Evidence

DOI10.6084/m9.figshare.5104873.v1
Patent numberUS08779131B2
Source datasetuspto-grants-2014_07
ORD IDord-6e53395b54504efc8339860f17ab6963
Source noteuspto-grants-2014_07