Sulfuric acid magnesium salt (1:1) → Simvastatin

Participants

Reaction Steps

100 g of simvastatin ammonium salt, 800 ml of chloroform, 43.2 g of p-toluenesulfonic acid monohydrate, and 20 g of anhydrous magnesium sulfate were added to a 1 L reaction flask, and the reaction mixture were allowed to stir at 15˜20° C. until the end of reaction. A TLC monitoring was carried out at the end of the reaction. Subsequently, simvastatin 80.2 g was obtained by the same procedure as described in example 3 with a yield of 86.93%, in which a content of simvastatin was 99.48%, and a content of a dimmer thereof was 0.14%.

Provenance & Evidence