反应详情

1-(4-Benzyloxyphenyl)-heptane-1,3-dione (191 mg; see Example 1 (a)), was suspended in 1 ml HBr/acetic acid and O-4-nitrophenylhydroxylamine, 100 mg, was added. The mixture was stirred at room temperature for 6 h. After quenching with water and extraction to EtOAc followed by evaporation of the solvent, a crude material containing approximately 125 mg of the title compound was obtained. Yield ca. 59%.

1. customAfter quenching with water and extraction to EtOAc
2. customfollowed by evaporation of the solvent
3. additiona crude material containing approximately 125 mg of the title compound
4. customwas obtained