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HRID1625475

反应详情

EQUATION

反应方程式

HRID 1625475 的结构方程式

REACTANTS

反应物

5
结构：CN(C)C=O
HCID6228

N,N-Dimethylformamide

C3H7NO

结构：CCN(C(C)C)C(C)C
HCID81531

Diisopropylethylamine

C8H19N

结构：NC(C(=O)O)c1cccs1
HCID89435

DL-2-Amino-2-thien-2-ylacetic acid

C6H7NO2S

结构：CN(C)C(On1nnc2cccnc21)=[N+](C)C.F[P-](F)(F)(F)(F)F
HCID9886157

Methanaminium, N-((dimethylamino)(3H-1,2,3-triazolo(4,5-b)pyridin-3-yloxy)methylene)-N-methyl-, hexafluorophosphate(1-) (1:1)

C10H15F6N6OP

结构：O=C(O)c1cccn(Cc2ccc(F)c(F)c2)c1=O
HCID53427969

1-[(3,4-Difluorophenyl)methyl]-2-oxo-1,2-dihydropyridine-3-carboxylic acid

C13H9F2NO3

PRODUCTS

生成物

1
结构：O=C(NC(C(=O)O)c1cccs1)c1cccn(Cc2ccc(F)c(F)c2)c1=O
HCID68609732

未命名化合物

PROCEDURE

实验过程

1-(3,4-Difluoro-benzyl)-2-oxo-1,2-dihydro-pyridine-3-carboxylic acid (0.23 g, 0.00088 mol;) was dissolved in N,N-Dimethylformamide (9 mL, 0.1 mol;) and N,N-Diisopropylethylamine (800 uL, 0.004 mol;), and N,N,N′,N′-Tetramethyl-O-(7-azabenzotriazol-1-yl)uronium Hexafluorophosphate (0.37 g, 0.00097 mol;) were added. After 5 minutes preactivation Amino-thiophen-2-yl-acetic acid (0.266 g, 0.00169 mol;) was added. Workup consisted of rinsing with 5% citric acid then brine after dissolving the crude in ethyl acetate. The organic layer was then dried with magnesium sulfate and concentrated. The crude material was brought on directly to the next step. ES (+) MS m/e=404.81

WORKUP

后处理

  1. washof rinsing with 5% citric acid
  2. dissolutionbrine after dissolving the crude in ethyl acetate
  3. dry with materialThe organic layer was then dried with magnesium sulfate
  4. concentrationconcentrated