Hydrochloric Acid → HCID 178419344, compound

Participants

Reaction Steps

A suspension of (S)-tert-butyl 2-(4-(4′-bromo-[1,1′-biphenyl]-4-yl)-1H-imidazol-2-yl)pyrrolidine-1-carboxylate (505 mg, 1.078 mmol) in HCl (4M in dioxane 5.4 mL, 21.6 mmol) is stirred at room temperature for 2 hours and diluted with diethyl ether (2 mL). The suspension is cooled in an ice bath and the product is collected by filtration to give (S)-4-(4′-bromo-[1,1′-biphenyl]-4-yl)-2-(pyrrolidin-2-yl)-1H-imidazole hydrochloride (436 mg, 99%).

Provenance & Evidence