Hydrochloric Acid → HCID 178502337, compound

Participants

Reaction Steps

To a solution of tert-butyl (2S)-2-[4-[4-[2-[(2S)-1-[(2S)-2-(methoxycarbonylamino)-3-methyl-butanoyl]pyrrolidin-2-yl]-1H-benzimidazol-5-yl]phenyl]-1H-imidazol-2-yl]pyrrolidine-1-carboxylate (100 mg, 0.1525 mmol) in MeOH (0.15 mL) is added HCl in dioxane (381.2 μL of 4 M, 1.525 mmol), stirred at rt overnight, then concentrated to afford 4-(4-(2-((S)-1-((S)-2-((methoxycarbonyl)amino)-3-methylbutanoyl)pyrrolidin-2-yl)-1H-benzo[d]imidazol-5-yl)phenyl)-2-((S)-pyrrolidin-1-ium-2-yl)-1H-imidazol-3-ium chloride (100 mg, 0.1529 mmol, 100.3%) as a light brown solid. LC-MS shows presence of desired compound which is used as such in the next step without further purification.

Provenance & Evidence