1,4-Dioxane hydrochloride → HCID 178461571, compound

Participants

Reaction Steps

To a solution of tert-butyl (2S,4S)-2-[4-[4-[2-[2-[(2S,4S)-1-tert-butoxycarbonyl-4-methyl-pyrrolidin-2-yl]-1H-benzimidazol-5-yl]ethynyl]phenyl]-1H-imidazol-2-yl]-4-methyl-pyrrolidine-1-carboxylate (56 mg, 0.086 mmol) in methanol (2 mL) is added 4M HCl/dioxane (430 uL, 1.72 mmol). The mixture is stirred at rt for 3 hours. Removal of the solvent under vacuum gives 2-[(2S,4S)-4-methylpyrrolidin-2-yl]-5-[2-[4-[2-[(2S,4S)-4-methylpyrrolidin-2-yl]-1H-imidazol-4-yl]phenyl]ethynyl]-1H-benzimidazole HCl salt. The crude is used directly in the next step.

Provenance & Evidence