HuagongsheHuagongshe Chemistry Print Report · For research reference only
Hydrochloric Acid → 4-iodo-2-[(2S,4S)-4-methylpyrrolidin-2-yl]-1H-imidazole
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Hydrochloric Acid | HCID 313 | — |
| Reactant | (2S,4S)-tert-butyl 2-(5-iodo-1H-imidazol-2-yl)-4-methylpyrrolidine-1-carboxylate | HCID 53261949 | — |
| Solvent | Methanol | HCID 887 | — |
| Solvent | 1,4-Dioxane | HCID 31275 | — |
| Product | 4-iodo-2-[(2S,4S)-4-methylpyrrolidin-2-yl]-1H-imidazole | HCID 178461573 | 116.5% |
Reaction Steps
To a solution of tert-butyl (2S,4S)-2-(4-iodo-1H-imidazol-2-yl)-4-methyl-pyrrolidine-1-carboxylate (1.6 g, 4.242 mmol) in MeOH (16 mL) is added a 4M HCl in dioxane solution (16 ml) at 0° C. The reaction mixture is stirred at RT overnight and evaporated to dryness to afford 4-iodo-2-[(2S,4S)-4-methylpyrrolidin-2-yl]-1H-imidazole (1.37 g, 92.5%) as a yellow solid.
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08779156B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-1af8b01bfe0d4590985a47a4cf4411a8 |
| Source note | uspto-grants-2014_07 |