Trifluoroacetic acid → HCID 178506537, compound

Participants

Reaction Steps

To a stirring mixture of (S)-2-(5-Iodo-1H-benzoimidazol-2-yl)-pyrrolidine-1-carboxylic acid tert-butyl ester (20 g, 48 mmol) in CH2Cl2 (200 mL) at 0° C. is added TFA (200 mL). The reaction mixture is stirred at room temperature for 2 hours and concentrated in vacuum. The residue is dissolved in CH2Cl2 and saturated aqueous NaHCO3, the organic layer is washed with saturated aqueous NaHCO3, dried over sodium sulfate and concentrated in vacuum to afford (S)-5-iodo-2-(pyrrolidin-2-yl)-1H-benzo[d]imidazole-TFA salt (12 g).

Provenance & Evidence