HuagongsheHuagongshe Chemistry Print Report · For research reference only
Propargyl bromide → (2S)-2-[methyl(prop-2-yn-1-yl)amino]-3-phenylpropan-1-ol
Participants
| Role | Name | HCID | Charge |
|---|---|---|---|
| Reactant | Propargyl bromide | HCID 7842 | — |
| Reactant | (S)-2-(Methylamino)-3-phenylpropan-1-ol | HCID 10888274 | — |
| Product | (2S)-2-[methyl(prop-2-yn-1-yl)amino]-3-phenylpropan-1-ol | HCID 57789236 | — |
Reaction Steps
Compound 1c is synthesized according to general procedure H from starting material 1b using 2.5 mmol of propargyl bromide (298 mg). The desired compound is obtained in 60% yield (243 mg, 1.2 mmol).
Provenance & Evidence
| DOI | 10.6084/m9.figshare.5104873.v1 |
|---|---|
| Patent number | US08784775B2 |
| Source dataset | uspto-grants-2014_07 |
| ORD ID | ord-c6da1d0bcdef40bcbdbe84cb6a3e0850 |
| Source note | uspto-grants-2014_07 |