Propargyl bromide → HCID 57789237, compound

HRID 1625540Notes

Reaction equation

[CH3:1][C@@H:2]1[C@H:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[O:5][C:4](=[O:13])[NH:3]1.[CH2:14](Br)[C:15]#[CH:16]>>[CH3:1][C@@H:2]1[C@H:6]([C:7]2[CH:12]=[CH:11][CH:10]=[CH:9][CH:8]=2)[O:5][C:4](=[O:13])[N:3]1[CH2:16][C:15]#[CH:14]

Participants

Reactant 2

HCID 7842Propargyl bromide

HCID 2733812(4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone

Product 1

HCID 57789237HCID 57789237, compoundYield 76%

Procedure

Compound 2a is synthesized from (4R,5S)-(+)-4-Methyl-5-phenyl-2-oxazolidinone (Aldrich) according to general procedure F using 15 mmol (1.79 g) propargyl bromide (Aldrich).

Sources & evidence

ORD record: ord-8c197f9c771b437b833d0aa2b2d30fe3
Source dataset: uspto-grants-2014_07
DOI: 10.6084/m9.figshare.5104873.v1
Patent number: US08784775B2

Reaction notes

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