2-(Bromomethyl)pyridine hydrobromide → HCID 57330262, compound

HRID 1625553Notes

Reaction equation

HRID 1625553 reaction equation
[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:10][C:11](=[S:14])[NH:12][N:13]=1.Br.Br[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1>>[CH3:1][C:2]1[CH:7]=[C:6]([CH3:8])[CH:5]=[CH:4][C:3]=1[C:9]1[NH:13][N:12]=[C:11]([S:14][CH2:17][C:18]2[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=2)[N:10]=1

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 178424080HCID 178424080, compound

Product 1

HCID 57330262HCID 57330262, compoundYield 64%

Procedure

Prepared in a similar manner to example 1 using 5-(2,4 dimethylphenyl)-2H-1,2,4-triazole-3(4H)-thione (example 3a) and 2-(bromomethyl)pyridine hydrobromide. Yield 64%. 1H NMR (500 MHz, CDCl3): δ 2.34 (s, 3H), 2.57 (s, 3H), 4.37 (s, 2H), 4.51 (s, 2H), 7.04-7.08 (m, 2H), 7.28-7.31 (m, 1H), 7.41-7.43 (d, 1H), 7.74-7.77 (m, 2H), 8.63-8.64 (d, 1H). MS (M+H, 297); mp=112-114° C.

Sources & evidence

ORD record
ord-11d3b72f12b747ac888d00a72f712b2a
Source dataset
uspto-grants-2014_07
Patent number
US08784782B2

Reaction notes

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