2-(Bromomethyl)pyridine hydrobromide → HCID 41539346, compound

HRID 1625555Notes

Reaction equation

HRID 1625555 reaction equation
[CH2:1]([C:3]1[CH:8]=[CH:7][C:6]([C:9]2[NH:10][C:11](=[S:14])[NH:12][N:13]=2)=[CH:5][CH:4]=1)[CH3:2].Br.Br[CH2:17][C:18]1[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=1>>[CH2:1]([C:3]1[CH:4]=[CH:5][C:6]([C:9]2[NH:13][N:12]=[C:11]([S:14][CH2:17][C:18]3[CH:23]=[CH:22][CH:21]=[CH:20][N:19]=3)[N:10]=2)=[CH:7][CH:8]=1)[CH3:2]

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 178435880HCID 178435880, compound

Product 1

HCID 41539346HCID 41539346, compoundYield 71%

Procedure

Prepared in a similar manner to example 1 using 5-(4-ethylphenyl)-2H-1,2,4-triazole-3(4H)-thione (example 4a) and 2-(bromomethyl)pyridine hydrobromide. Yield 71%. 1H NMR (500 MHz, dMSO): δ 1.18-1.22 (t, 3H), 2.64-2.66 (t, 2H), 4.52 (s, 2H), 7.30-7.88 (m, 8H), 14.3 (bs, 1H). MS (M+H, 297).

Sources & evidence

ORD record
ord-2e92eacd26ab4d70918a72b800656db4
Source dataset
uspto-grants-2014_07
Patent number
US08784782B2

Reaction notes

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