2-(Bromomethyl)pyridine hydrobromide → HCID 58755925, compound

HRID 1625561Notes

Reaction equation

HRID 1625561 reaction equation
[CH3:1][O:2][C:3]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:4]=1[CH2:5][C:6]1[NH:7][C:8](=[S:11])[NH:9][N:10]=1.Br.Br[CH2:20][C:21]1[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=1>>[CH3:1][O:2][C:3]1[CH:15]=[C:14]([O:16][CH3:17])[CH:13]=[CH:12][C:4]=1[CH2:5][C:6]1[NH:10][N:9]=[C:8]([S:11][CH2:20][C:21]2[CH:26]=[CH:25][CH:24]=[CH:23][N:22]=2)[N:7]=1

Participants

3

Reactant 2

HCID 27347202-(Bromomethyl)pyridine hydrobromideHCID 1784899425-(2,4-dimethoxybenzyl)-4H-1,2,4-triazole-3-thiol

Product 1

HCID 58755925HCID 58755925, compoundYield 34%

Procedure

Prepared in a similar manner to example 1 using 5-(2,4-dimethoxybenzyl)-2H-1,2,4-triazole-3(4H)-thione (example 9a) and 2-(bromomethyl)pyridine hydrobromide. Yield 34%. 1H NMR (500 MHz, CDCl3): δ 3.77 (s, 3H), 3.79 (s, 3H), 4.0 (s, 2H), 4.34 (s, 2H), 6.35-6.45 (m, 2H), 7.1 (d, 1H), 7.15 (t, 1H), 7.3 (d, 1H), 7.7 (t, 1H), 8.5 (s, 1H). MS (M+H, 343).

Sources & evidence

ORD record
ord-3b98fa68e48d478cb5c43230c03cc70f
Source dataset
uspto-grants-2014_07
Patent number
US08784782B2

Reaction notes

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